王祥瑞

职 称：主任医师

职 务：疼痛科主任

院 区：东院，南院

科 室：麻醉科

医疗专长：研究及擅长心血管手术麻醉管理，围术期液体治疗，临床监测，危重疾病诊治以及疼痛治疗。在疼痛治疗方面采用各种微创神经介入技术，椎间孔镜微创手术治疗椎间盘突出症，神经毁损治疗顽固性癌痛和带状疱疹后遗神经痛，腰

门诊时间：东院 每周一上午 南院 每周三上午

教育经历

1982年获医学学士学位，1990年获麻醉学硕士学位，1995年获药理学博士学位。

学术职务

中国医师学会麻醉分会常委，中华医学会疼痛分会全国委员，中华针灸学会针刺麻醉理事会副主任委员，中医药促进会软组织疼痛分会副主任委员，中华医学会麻醉学分会委员会委员，上海医学会麻醉学会副主任委员，上海医学会危重病学会委员，上海医学会疼痛专业委员会主任委员，上海针灸学会针刺麻醉分会副主任委员

论文著作

1、 A preliminary study on the monitoring of mixed venous oxygen saturation through the left main bronchus. Critical Care 2006, 10:R7-R13

Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha. Cell Res. 2006 Jun;16(6):548-58

3、Low hematocrit worsens cerebral injury after prolonged hypothermic circulatory arrest in rats. CAN J ANESTH 2006 , 53( 12 ): 1220–1229

4、Up-regulation of Hypoxia Inducible Factor 1alpha by Isoflurane in Hep3B Cells. Anesthesiology. 2006 Dec;105(6):1211-1219

5、Activations of mitogen-activated protein kinase and nuclear factor-kappaB by mechanical stretch result in ventilation-induced lung injury. 2007;68:356-360 Med Hypotheses.

6、Response of Alveolar Type II Epithelial Cells to Mechanical Stretch and Lipopolysaccharide. 2007;74(5):579-85 Respiration

7、Dose-dependent neuroprotection of delta opioid peptide [D-Ala2, D-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats. 2007;423(2):113-7 Neurosci Lett.

8、Role of Rel A and IkappaB of nuclear factor kappaB in the release of interleukin-8 by cyclic mechanical strain in human alveolar type II epithelial cells A549. 2007 Nov;12(6):792-8 Respirology.

9、Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats. 2008Jan 31;431(2):129-34. Neurosci Lett

10、Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res.2009Oct 6;1292:100-106.

11、In reply to ‘‘Is intrathecal lidocaine administration risk-free in rats with neuropathic pain?” Eur J Pain.2009, 13(6):891

12、Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain.2009 Feb;13(2):130-137

13、Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection. Cancer Sci.2010 Feb;101(2):412-415

14、Resection of the nerves bundle from the sphenopalatine ganglia tend to increase the infarction volume following middle cerebral artery occlusion. Neurol Sci.2010 Aug;31(4):431-435

15、Lidocaine attenuates proinflammatory cytokine production induced by extracellular adenosine triphosphate in cultured rat microglia. Anesth Analg. 2010 Sep;111(3):768-774

16、Time course of action and pharmacokinetics of ropivacaine in adult and elderly patients following combined lumbar plexus-sciatic nerve block. Int J Clin Pharmacol Ther.2010 Sep;48(9):608-613

17、Repeated but not single isoflurane exposure improved the spatial memory of young adult mice.. Acta Anaesthesiol Scand,2011;55(4):468-473.

18、Delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia.. Eur J Pharmacol,2011;658(2-3):140-144.

19、Hydroxyethyl Starch (130 kD) Inhibits Toll-Like Receptor 4 Signaling Pathways in Rat Lungs Challenged with Lipopolysaccharide.. Anesth Analg,2011;113(1):112-119

20、Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil.. PLoS One.,2011;6(11):e27632.

21、Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice.. World J Gastroenterol.,2011;17(48):5267-5273.

22、Isoflurane Exposure during Mid-Adulthood Attenuates Age-Related Spatial Memory Impairment in APP/PS1 Transgenic Mice. PLoS One.,2012;7(11):e50172.

23、Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.. J Surg Res.,2012;175(2):e61-66.

24、Protective Effects of the Delta Opioid Peptide [D-Ala2, D-Leu5]enkephalin in an Ex Vivo Model of Ischemia/Reperfusion in Brain Slices.. CNS Neurosci Ther.,2012;18(9):762-766.

25、Changes in pressure pain thresholds and Basal electromyographic activity after instrument-assisted spinal manipulative therapy in asymptomatic participants: a randomized, controlled trial.. J Manipulative Physiol Ther.,2012;35(6):437-445.

26、Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system.. Anesthesiology.,2012;116(2):406-414

27、Lipopolysaccharide Induces Lung Fibroblast Proliferation through Toll-Like Receptor 4 Signaling and the Phosphoinositide3-Kinase-Akt Pathway.. PLoS ONE,2012;7(4):e35926

28、Isoflurane Prevents Neurocognitive Dysfunction After Cardiopulmonary Bypass in Rats.. J Cardiothorac Vasc Anesth.,2013 Jun;27(3):502-9.

29、Epigenetic regulation of Thy-1 gene expression by histone modification is involved in lipopolysaccharide-induced lung fibroblast proliferation.J Cell Mol Med. 2013 Jan;17(1):160-7.

30. TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury. Lab Invest, 2013 Jul;93(7):792-800.

31. Toll-like receptor 4 mediates acute lung injury induced by high mobility group box-1. PLoS One, 2013 May 17;8(5):e64375.

32. Smaller Sized Inhaled Anesthetics have More Potency on Senescence-Accelerated Prone-8 Mice Compared with Senescence-Resistant-1 Mice. J Alzheimers Dis, 2013 Oct.

创新专利实用新型专利：

支气管内环境微型无创压力温度监测装置

气管插管牙齿保护套

经气道无创监测混合静脉血氧饱和度气管导管

支气管内环境微型无创pH值监测装置

电针调控人体循环生物信息伺服装置

针刺镇痛生物信息整合与反馈装置

人体疼痛生物信息多参数整合即时评估装置

呼吸道高压氧气喷射给药装置

获得荣誉2006年，针麻心脏手术心肺保护作用及机制研究，获中国针灸学会(二等奖);

2006年，复合针刺技术对围术期缺血心肌保护作用及其机制研究，获上海市医学奖(三等奖);

2008年，手术病人循环功能调控新策略，获上海市科技进步奖(三等奖);

2009年，低氧耐受及呼吸道压力生物学效应与术后肺部并发症;

2009年，上海市育才奖